Ozone Therapy in Greenville, SC
Ozone Therapy at IHP Greenville. Dr. Hendry, DAOM — functional medicine, root-cause diagnostics, personalized care. Call (864) 365-6156.
Medical ozone therapy is one of the most evidence-supported yet underutilized treatments in integrative medicine. At Integrative Health Partners in Greenville, SC, Dr. William Hendry — a member of the American Academy of Ozone Therapy (AAOT) — offers ozone therapy as part of a comprehensive integrative protocol for chronic infections, inflammatory conditions, immune dysregulation, autoimmune disease, and systemic toxicity.
Ozone (O₃) is a molecule consisting of three oxygen atoms. When administered in a medical context at therapeutic concentrations, ozone acts as a powerful biological signaling molecule — not as a toxin or oxidant as commonly misunderstood. It works by inducing a brief, controlled oxidative stress response that activates the body's antioxidant defense systems (superoxide dismutase, glutathione, catalase), stimulates immune cell production, and enhances oxygen utilization at the cellular level via upregulation of the 2,3-DPG pathway in red blood cells.
The result is a cascade of biological benefits: antimicrobial action against bacteria, viruses, fungi, and parasites; anti-inflammatory modulation via prostaglandin E2 suppression; enhanced circulation through increased red blood cell flexibility; and cellular detoxification through upregulation of the Nrf2 pathway. Unlike antibiotics or immunosuppressants, ozone therapy does not cause resistance, deplete the microbiome, or damage healthy tissue when administered at proper therapeutic concentrations by a trained practitioner.
How Ozone Therapy Works
Dr. Hendry offers ozone therapy via multiple administration routes, selected based on your condition and therapeutic goals. The most common approaches at IHP include rectal insufflation (ozone gas administered rectally — the most systemic delivery route for gut, immune, and liver conditions), ozone steam sauna (full-body transdermal delivery for detoxification and skin conditions), ear and nasal insufflation (for sinus, ear, and upper respiratory conditions), and direct injection into joints or trigger points (prolotherapy-adjacent approach for chronic joint pain and musculoskeletal conditions).
Each session begins with a health status check and a brief review of symptoms since the last visit. Ozone is generated fresh at the time of treatment using medical-grade oxygen — it cannot be bottled or stored. Concentrations and volumes are measured precisely for each treatment. Sessions typically run 30–60 minutes depending on the administration route.
Conditions Treated with Ozone Therapy
Ozone Therapy vs. Antibiotic and Immunosuppressant Approaches
For chronic infections (Lyme disease, EBV, mycoplasma), antibiotics often fail to eradicate pathogens that have adopted intracellular or biofilm-protected survival strategies. Ozone therapy disrupts biofilm structures, penetrates intracellular compartments, and kills pathogens through oxidative mechanisms that cannot generate antibiotic resistance. For autoimmune conditions, immunosuppressants reduce the immune attack but expose patients to infection risk and do not address the inflammatory triggers driving the autoimmune process. Ozone therapy modulates — rather than suppresses — the immune system, reducing aberrant inflammatory responses while improving pathogen clearance. The two approaches are not mutually exclusive; Dr. Hendry often uses ozone therapy as an adjunct to help patients who are partially responsive to conventional treatment achieve more complete resolution.
Research & Evidence
The European and International Ozone Associations (EOA, ISCO3) have published consensus guidelines based on decades of European clinical research demonstrating ozone therapy efficacy for ischemic conditions, chronic infections, diabetic foot ulcers, herniated discs, and inflammatory disease. A 2019 systematic review in the International Journal of Molecular Sciences documented ozone therapy's ability to modulate Nrf2 — the master antioxidant pathway — explaining its paradoxical anti-inflammatory action. Research in Germany (where ozone therapy has been mainstream for 50+ years) documents efficacy for over 40 conditions. Dr. Hendry integrates these international research findings with his clinical experience to select appropriate ozone protocols for each patient.
Cost & Insurance Information
Ozone therapy sessions are priced by administration route and session length. A package of sessions is often more cost-effective than individual visits. Ozone therapy is not typically covered by insurance, though HSA/FSA accounts may be used. Dr. Hendry discusses costs transparently at your initial consultation so you can plan your treatment course. Call (864) 365-6156 for current pricing.
Treatment Timeline
Your First Appointment
Before your first ozone therapy session, Dr. Hendry reviews your complete health history and current medications. Ozone therapy is contraindicated in G6PD deficiency (a genetic enzyme disorder) and during active hyperthyroidism — he will screen for these before proceeding. Depending on the administration route, you may be asked to eat lightly beforehand. Come prepared to discuss your primary symptoms, any recent infections or immune challenges, and your goals for treatment. Most patients notice improved energy and reduced inflammatory symptoms after their first 3–5 sessions.
Why Dr. Hendry for Ozone Therapy
Dr. Hendry's AAOT membership reflects his commitment to staying at the frontier of evidence-based ozone therapy. His functional medicine background allows him to interpret ozone therapy not as an isolated treatment but as part of a systems-level therapeutic strategy — often combined with acupuncture, Chinese herbal medicine, targeted supplementation (particularly glutathione), and dietary protocol. His research experience at Prisma Health informs his ability to evaluate ozone therapy literature critically and apply it with clinical rigor.