Fatigue, Brain & Nervous System Conditions
Functional medicine and acupuncture for chronic fatigue syndrome, Long COVID, brain fog, anxiety, depression, insomnia, PTSD, peripheral neuropathy, and cognitive decline. Comprehensive neurological and biological evaluation — with published research in heart rate variability biofeedback and needle-based neurological therapies behind the clinical protocols.
A Note From Dr. Hendry
The brain and nervous system operate at the intersection of every other body system — hormonal, immunological, gut-based, mitochondrial. When neurological and fatigue conditions haven't responded to conventional treatment, it's almost always because the evaluation stopped too early. Standard labs found nothing. Nobody checked the cortisol rhythm, the mitochondrial function markers, the gut microbiome, or the viral titers. The biology that explains these conditions is real and measurable — it just requires looking for it.
My published research includes heart rate variability biofeedback for symptom management — which means I work with autonomic nervous system regulation as a clinical variable, not just a theoretical concept. HRV is a direct window into the balance between sympathetic activation and parasympathetic recovery — and it's measurably disrupted in anxiety, PTSD, chronic fatigue, and fibromyalgia. I use it as an objective treatment monitoring tool.
I co-authored research on acupuncture for taxane-induced peripheral neuropathy at Prisma Health. When a neuropathy patient comes in, I'm applying a research-developed protocol — not working from general principles.
Conditions Covered at This Hub
Chronic Fatigue Syndrome / ME-CFS — Post-exertional malaise defines this condition: not tiredness, but a worsening of all symptoms 12–48 hours after even mild exertion. This reflects mitochondrial dysfunction, HPA axis dysregulation, NK cell impairment, neuroinflammation, and gut dysbiosis. Standard panels miss all of it. Organic acids, four-point cortisol, viral titers, and microbiome analysis identify the actual drivers. Pacing is fundamental; conventional graded exercise therapy is contraindicated.
Brain Fog — A symptom with many roots: neuroinflammation from gut dysbiosis or post-viral effects, thyroid dysfunction, blood sugar dysregulation, hormonal imbalance, B12 or iron deficiency, or mitochondrial impairment. Most brain fog has identifiable biological drivers — they appear on targeted testing. Post-COVID brain fog involves active neuroinflammation, endothelial dysfunction, and mitochondrial damage.
Anxiety & Stress — Anxiety has a biology. HPA axis dysregulation, magnesium deficiency (in up to 70% of Americans), gut dysbiosis reducing GABA production, and thyroid dysfunction generate anxiety independently. Acupuncture modulates amygdala activity, increases GABA, reduces cortisol — results confirmed in multiple meta-analyses. I identify the physiological drivers rather than treating anxiety as a purely psychological condition.
Depression — Neuroinflammation is a central mechanism — inflammatory cytokines disrupt serotonin synthesis and reduce BDNF. The 'chemical imbalance' model has led generations of patients to antidepressants without checking their B12, vitamin D, thyroid, or inflammatory markers. I coordinate with psychiatrists, contributing biological substrate correction that makes the brain more responsive to all treatment.
Insomnia — Sleep requires specific physiology: declining cortisol, rising melatonin, parasympathetic dominance, stable blood sugar. My HRV research gives me an objective window into autonomic state — whether the sympathetic nervous system is still dominant at bedtime. Low progesterone, high evening cortisol, and nocturnal hypoglycemia explain most insomnia that doesn't respond to sleep hygiene.
PTSD — A neurological state. The amygdala is hyperactivated; the prefrontal cortex can't reliably override it. Battlefield Acupuncture and body acupuncture reduce sympathetic hyperarousal at the physiological level — complementing psychological treatment by making the nervous system more accessible to therapeutic work. I work with trauma-informed awareness and adjust technique for touch-sensitive patients.
Peripheral Neuropathy — I co-authored research on taxane-induced peripheral neuropathy at Prisma Health. Electroacupuncture improves nerve conduction velocity and promotes nerve regeneration through NGF expression. For diabetic neuropathy, functional medicine addresses blood sugar optimization, mitochondrial support, and nutritional deficiencies (B12 in metformin users, alpha-lipoic acid, acetyl-L-carnitine).
Cognitive Decline & Alzheimer's Prevention — The biology of Alzheimer's begins 15–20 years before symptoms. Insulin resistance in the brain, neuroinflammation, hormonal decline, elevated homocysteine, heavy metals, and sleep disruption impairing glymphatic clearance are all identifiable and modifiable. My comprehensive evaluation identifies them specifically. Scalp acupuncture targeting the memory cortex has the most specific clinical evidence base for cognitive support.
Frequently Asked Questions
What tests does Dr. Hendry run for unexplained fatigue?
Beyond standard blood work: four-point salivary cortisol, comprehensive thyroid panel, B12/methylmalonic acid (functional B12 status), iron studies, vitamin D, organic acids (mitochondrial function), inflammatory markers (hsCRP, homocysteine), viral titers (EBV, CMV, HHV-6), and gut microbiome assessment. Standard CBC and metabolic panels miss the drivers of the majority of chronic fatigue cases.
What is causing my 2–3am waking?
Early morning waking (2–4am) is most commonly associated with blood sugar drops triggering a cortisol response, or low progesterone in perimenopausal women (progesterone supports GABA-mediated sleep and is lowest in the early morning hours). High evening cortisol from HPA axis dysregulation also keeps the nervous system activated into the early morning. The cortisol rhythm, glucose regulation, and hormonal status together identify which mechanism is active.
Can depression have a physical cause?
Very commonly. Hypothyroidism mimics depression and is one of the most commonly missed reversible causes. B12, omega-3, folate, iron, zinc, and vitamin D deficiencies are each independently associated with depressive symptoms. Neuroinflammation from gut dysbiosis disrupts serotonin synthesis and reduces BDNF. Testing and correcting these factors can resolve depression that hasn't responded to antidepressants.
Can neuropathy be reversed?
Peripheral nerves regenerate slowly — approximately 1–2mm per day. The degree of recovery depends on type, mechanism, and severity of damage. Diabetic neuropathy requires blood sugar optimization alongside nerve support; B12 deficiency neuropathy resolves with repletion; chemotherapy-induced neuropathy responds to electroacupuncture. Early intervention gives the best prognosis.
How early should I address cognitive decline risk?
The biology of Alzheimer's begins 15–20 years before symptoms appear. Most modifiable drivers — insulin resistance, sleep apnea, B12 deficiency, thyroid dysfunction, heavy metal burden — are identifiable and correctable now. The highest-impact intervention window is in your 40s through 60s. If you're noticing cognitive symptoms — even subtle ones — evaluation makes sense immediately.
Services for Neurological & Fatigue Conditions
Ready to Get to the Root of It?
Dr. William Hendry will conduct a comprehensive evaluation and build an integrative treatment plan around your specific condition. New patients welcome in Greenville, SC.