Ozone Therapy in Greenville, SC
Ozone Therapy at IHP Greenville. Dr. Hendry, DAOM — functional medicine, root-cause diagnostics, personalized care. Call (864) 365-6156.
"I have to say that finding this clinic was a true miracle. At the beginning of 2019 I got to the low point of my health and landed in the ER. Medical doctors told me I just had a GI issue and should just take some meds for it. Dr. Hendry changed everything for me."
— Tat V. · April 2020 · Google Review
Most patients who call about ozone therapy start by apologizing — "I know this sounds weird, but..." It doesn't sound weird to me. I've been following the European literature on ozone for years, and the clinical outcomes for chronic infection, immune dysregulation, and gut disease are better documented than most of what gets written as standard-of-care protocol.
Here's the basic science. Ozone is O₃ — three oxygen atoms. At ambient concentrations it's a pollutant that damages lung tissue. At therapeutic concentrations from medical-grade oxygen, delivered via the routes we use — rectal insufflation, steam sauna, ear insufflation, joint injection — it works as a biological signaling molecule. Your body responds to a controlled micro-dose of oxidative stress the same way it responds to exercise: antioxidant enzyme production spikes (superoxide dismutase, glutathione, catalase), immune cell output increases, and cellular oxygen utilization improves through the 2,3-DPG pathway in red blood cells.
The result isn't symptom suppression. It's activation of the systems that handle pathogens, inflammation, and cellular repair — without antibiotic resistance, without microbiome disruption, without the systemic side effects of immunosuppression. Germany has been using ozone therapy in mainstream clinical practice for more than 50 years. The literature reflects that. I'm an American Academy of Ozone Therapy (AAOT) member, and I use it as part of a full functional protocol — not a standalone cure-all — for patients dealing with chronic infections, post-COVID fatigue, autoimmune flares, and gut dysbiosis that conventional approaches haven't resolved.
How Ozone Therapy Works
The route I recommend depends entirely on what we're treating. For gut conditions, chronic infections, immune dysregulation, and systemic presentations — the primary route is rectal insufflation. I know that sounds alarming, but it isn't uncomfortable, and it's the most effective systemic delivery available outside of IV ozone. Ozone gas administered rectally is absorbed into portal circulation and reaches the liver, gut-associated lymphoid tissue, and systemic immune system within minutes.
For joint pain, tendinopathy, and musculoskeletal conditions, I inject ozone directly into the affected joint or tissue — a prolotherapy-adjacent approach that drives local anti-inflammatory and regenerative signaling without the catabolic effects of cortisone.
For ear, sinus, and upper respiratory infections, ear and nasal insufflation is the appropriate route. The ozone steam sauna handles transdermal delivery for detoxification and skin conditions.
One important detail: ozone is generated fresh from medical-grade oxygen at the time of treatment. It can't be stored or bottled. What you're receiving is freshly produced, concentration-verified therapeutic gas — not a supplement you picked up somewhere. Every session starts with a brief health check and symptom review. Sessions run 30 to 60 minutes depending on the route.
Conditions Treated with Ozone Therapy
Ozone Therapy vs. Antibiotic and Immunosuppressant Approaches
For chronic infections (Lyme disease, EBV, mycoplasma), antibiotics often fail to eradicate pathogens that have adopted intracellular or biofilm-protected survival strategies. Ozone therapy disrupts biofilm structures, penetrates intracellular compartments, and kills pathogens through oxidative mechanisms that cannot generate antibiotic resistance. For autoimmune conditions, immunosuppressants reduce the immune attack but expose patients to infection risk and do not address the inflammatory triggers driving the autoimmune process. Ozone therapy modulates — rather than suppresses — the immune system, reducing aberrant inflammatory responses while improving pathogen clearance. The two approaches are not mutually exclusive; Dr. Hendry often uses ozone therapy as an adjunct to help patients who are partially responsive to conventional treatment achieve more complete resolution.
Research & Evidence
The European and International Ozone Associations (EOA, ISCO3) have published consensus guidelines based on decades of European clinical research demonstrating ozone therapy efficacy for ischemic conditions, chronic infections, diabetic foot ulcers, herniated discs, and inflammatory disease. A 2019 systematic review in the International Journal of Molecular Sciences documented ozone therapy's ability to modulate Nrf2 — the master antioxidant pathway — explaining its paradoxical anti-inflammatory action. Research in Germany (where ozone therapy has been mainstream for 50+ years) documents efficacy for over 40 conditions. Dr. Hendry integrates these international research findings with his clinical experience to select appropriate ozone protocols for each patient.
Cost & Insurance Information
Ozone therapy sessions are priced by administration route and session length. A package of sessions is often more cost-effective than individual visits. Ozone therapy is not typically covered by insurance, though HSA/FSA accounts may be used. Dr. Hendry discusses costs transparently at your initial consultation so you can plan your treatment course. Call (864) 365-6156 for current pricing.
Treatment Timeline
Your First Appointment
Before your first ozone therapy session, Dr. Hendry reviews your complete health history and current medications. Ozone therapy is contraindicated in G6PD deficiency (a genetic enzyme disorder) and during active hyperthyroidism — he will screen for these before proceeding. Depending on the administration route, you may be asked to eat lightly beforehand. Come prepared to discuss your primary symptoms, any recent infections or immune challenges, and your goals for treatment. Most patients notice improved energy and reduced inflammatory symptoms after their first 3–5 sessions.
Why Dr. Hendry for Ozone Therapy
Dr. Hendry's AAOT membership reflects his commitment to staying at the frontier of evidence-based ozone therapy. His functional medicine background allows him to interpret ozone therapy not as an isolated treatment but as part of a systems-level therapeutic strategy — often combined with acupuncture, Chinese herbal medicine, targeted supplementation (particularly glutathione), and dietary protocol. His research experience at Prisma Health informs his ability to evaluate ozone therapy literature critically and apply it with clinical rigor.